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Protein-Polymer Conjugation Services
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    Protein-Polymer Conjugation Services

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    PASylation TechnologyPolysialylation PlatformPEGylation Services

    We provide comprehensive protein-polymer conjugation services that help transform biologics into safer, longer-lasting, and more effective therapies. By leveraging advanced chemistries such as PEGylation, PASylation, and polysialylation, we can covalently attach polymers to therapeutic proteins, peptides, and enzymes. This modification not only extends half-life and improves pharmacokinetics but also enhances stability, reduces immunogenicity, and optimizes drug delivery profiles. With expertise across R&D and GMP-compliant process development, our team supports biotech startups, pharmaceutical companies, and research institutions seeking scalable solutions for next-generation biologics.

    What Problems Does Protein-Polymer Conjugation Solve?

    Short half-life in vivo: Native proteins are often cleared too quickly from the bloodstream. Conjugation dramatically extends circulation time.

    Poor stability & aggregation: Polymer shielding reduces denaturation, aggregation, and proteolytic degradation.

    Immunogenicity & side effects: Smart polymer modifications help reduce immune recognition and off-target responses.

    Limited bioavailability & targeting: Tailored polymer conjugates enhance tissue penetration and controlled release.

    Manufacturing bottlenecks: Custom conjugation strategies streamline downstream purification and formulation.

    Our Protein-Polymer Conjugation Services

    antibodyCustom Polymer Conjugation Design
    • Multiple Platforms - PEGylation, PASylation, and polysialylation tailored to different therapeutic proteins.
    • Site-Specific or Random Conjugation - Flexible strategies to balance activity retention with stability.
    • Polymer Optimization - Selection of polymer size, structure, and chemistry to maximize half-life extension.
    • Application Versatility - Suitable for enzymes, cytokines, hormones, and antibody fragments.
    antibodyPEGylation Services
    • PEG Reagent Selection & Supply - Custom selection of PEG molecular weight, structure (linear, branched), and functional groups.
    • Site-Specific or Random Conjugation - Development of strategies for N-terminal, cysteine, or lysine PEGylation.
    • Conjugation Reaction Optimization - Fine-tuning of reaction conditions for maximum yield and activity retention.
    • Analytical Verification - Characterization of PEGylated proteins, including conjugation ratio, molecular weight, and activity assays.
    antibodyPASylation Services
    • PAS Sequence Design - In silico and experimental design of proline/alanine/serine-rich polypeptides with customized length.
    • Gene Fusion & Expression - Engineering of PAS-tagged proteins via recombinant DNA technology in suitable host cells.
    • Production & Purification - Scalable expression, fermentation, and purification of PASylated proteins.
    • Bioanalytical Characterization - Confirmation of PAS sequence integration, molecular size, stability, and bioactivity.
    antibodyPolysialylation Services
    • PSA Polymer Supply & Activation - Provision and activation of polysialic acid with defined chain lengths and reactive groups.
    • Conjugation Strategy Development - Establishment of optimized chemistry for protein-PSA attachment.
    • Process Scale-Up - Transition from lab-scale conjugation to pilot and GMP-compatible production.
    • Quality Control Testing - Analytical evaluation of conjugation efficiency, stability, and pharmacokinetic improvements.
    antibodyAnalytical Characterization
    • Conjugation Efficiency - Determination of polymer-to-protein ratio and attachment confirmation.
    • Structural Integrity - Molecular weight distribution and verification of conjugation sites.
    • Stability Studies - Assessment under stress conditions such as heat, pH, and proteolysis.
    • Bioactivity Testing - Ensuring functional performance of conjugates compared with the native protein.
    antibodyScale-up & GMP Manufacturing Support
    • Process Development - Optimization of reaction conditions and purification methods for scalability.
    • Pilot to GMP Transition - Stepwise scale-up with reproducibility and regulatory compliance in mind.
    • Documentation & Validation - Full process documentation and validation protocols for regulatory filings.
    antibodyHalf-life Extension Platforms

    Proven Technologies - PEGylation and PASylation platforms validated in preclinical studies.

    Reduced Dosing Frequency - Longer circulation half-life improves patient compliance and convenience.

    Broad Therapeutic Applications - Applied to hormones, cytokines, enzymes, and antibody fragments.

    Customizable Solutions - Tailored to client-specific pharmacokinetic and therapeutic goals.

    antibodyFormulation & Drug Delivery Consulting
    • Stability Enhancement - Formulation strategies to prevent aggregation and extend shelf life.
    • Controlled Release Systems - Integration of conjugates into delivery platforms for sustained release.
    • Compatibility Testing - Evaluation of excipients and buffers for optimal performance.
    • Regulatory Alignment - Support to ensure formulations meet global stability and safety standards.

    Step-by-Step Protein-Polymer Conjugation Process

    Expertise
    Consultation & Project Design

    We begin with a detailed consultation to understand your therapeutic protein, project goals, and regulatory requirements. Together, we design the most suitable conjugation strategy.

    Customization
    Feasibility Study

    Our scientists conduct proof-of-concept experiments to evaluate conjugation efficiency, activity retention, and stability improvements.

    Quality assurance
    Optimization & Scale-Up

    Once feasibility is confirmed, we optimize conjugation chemistry, purification, and formulation, then scale up for preclinical or clinical studies.

    Timely delivery
    Analytical Characterization

    Comprehensive testing is performed to confirm product quality, including molecular weight distribution, conjugation sites, stability, and immunogenicity profiles.

    Collaborative approach
    GMP Manufacturing Support

    We provide full support for GMP process development and regulatory documentation, ensuring a smooth path to IND and clinical production.

    Protein-Polymer Conjugation Benefits at a Glance

    Customizable Options
    Custom Conjugation Strategies

    We offer flexible design options including PEGylation, PASylation, and polysialylation, enabling tailored solutions that address your specific protein type and therapeutic application.

    Customizable Options
    Enhanced Protein Performance

    Our conjugation technologies significantly improve half-life, solubility, and stability while reducing immunogenicity, helping your biologics achieve better clinical outcomes.

    Customizable Options
    Seamless Scale-Up to GMP

    From bench to production, we develop robust, reproducible processes that scale smoothly into GMP environments, accelerating your pathway to commercialization.

    Customizable Options
    End-to-End Support

    Beyond conjugation, we provide formulation guidance, delivery optimization, and documentation support, offering a true one-stop solution for protein–polymer conjugate development.

    Applications of Protein-Polymer Conjugation

    Biopharmaceuticals
    • Extended Half-Life Therapeutics - Improve circulation time for cytokines, hormones, and enzymes, reducing dosing frequency.
    • Stability Enhancement - Increase formulation stability and reduce aggregation in therapeutic proteins and antibody fragments.
    • Reduced Immunogenicity - Minimize immune responses to biologics, improving patient safety and tolerability.
    Enzyme Replacement Therapy
    • Prolonged Enzyme Activity - Ensure longer enzymatic function in vivo for rare disease treatments.
    • Optimized Pharmacokinetics - Control clearance rates and biodistribution of therapeutic enzymes.
    • Improved Patient Compliance - Enable less frequent dosing and better treatment adherence.
    Oncology & Immunotherapy
    • Targeted Drug Delivery - Enhance delivery of antibody fragments, cytokines, and immune-modulators to tumors.
    • Reduced Side Effects - Polymer shielding decreases off-target activity and systemic toxicity.
    • Combination Therapies - Conjugates serve as part of multi-modal cancer treatment strategies.
    Vaccines & Prophylactics
    • Antigen Stabilization - Improve shelf-life and thermal stability of protein-based vaccines.
    • Controlled Release - Enable sustained immune stimulation through polymer-modified vaccine components.
    • Enhanced Immunogenicity Balance - Reduce adverse immune responses while preserving efficacy.
    Diagnostic & Research Tools
    • Improved Protein Reagents - Increase solubility and stability of proteins used in assays and imaging.
    • Longer Shelf Life - Extend usability of diagnostic proteins and biosensor components.
    • Custom Research-Grade Conjugates - Provide tailored modifications for preclinical and translational research.

    Frequently Asked Questions (FAQs)

    What is protein-polymer conjugation?

    Protein-polymer conjugation is the covalent attachment of polymers (such as PEG, PAS, or polysialic acid) to therapeutic proteins, peptides, or enzymes to improve their pharmacological properties.

    What are the main benefits of this technology?

    It extends protein half-life, enhances stability, reduces immunogenicity, improves bioavailability, and supports more patient-friendly dosing regimens.

    We specialize in PEGylation, PASylation, and polysialylation, but also offer custom solutions with novel polymers based on client needs.

    Absolutely. We offer end-to-end services from early feasibility studies through to GMP-compliant process development and manufacturing support.

    Ready to Transform Your Biologics?

    Unlock the full potential of your therapeutic proteins with our protein-polymer conjugation services. Whether you need custom PEGylation, PASylation, or polysialylation, our experts deliver end-to-end solutions from early research to GMP manufacturing support. Contact us today for a consultation or request a quote-and take the next step toward safer, longer-lasting, and more effective biologics.

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