Antibody Conjugation Services
Service Description
BOC Sciences provides personalized antibody conjugation services to support research and development in the field of antibody drugs. As a leading service provider of bioconjugation, our antibody conjugation services include antibody conjugated PEG, biotin, fluorescence dye, enzyme and oligonucleotide, which have been proven to improve the function and performance of antibody drugs, as well as to use for imaging and detection. Furthermore, antibody-drug conjugation services are provided to support the forefront of antibody-drug conjugates (ADCs) development.
What is Antibody Conjugation?
Antibody-based drugs have become an important class of biological drugs. The monoclonal antibody (mAb) and its derivatives, such as antibody-drug conjugates (ADCs), bispecific antibodies, have been widely used in the effective treatment of human diseases, particularly in the fields of immunology and oncology. In antibody-based therapy, various antibody derivatization approaches are used to improve the performance of antibodies or to test antibody drugs. For instance, the conjugation of PEG to antibodies can enhance the solubility of antibodies, reduce immunogenicity, and increase the circulating half-lives of antibodies. In addition, exploiting the character of antibodies binding specifically to antigens, antibodies labeled with chromogenic agents, such as fluorophore, enzyme, biotin, etc., provides a tool for the localization, characterization and quantification of antigens in biological tissues. With increased understanding of immunobiology and the continued development of molecular biology methods, it is believed that the possibilities of antibody-based therapeutics are bounded only by the scope of human ingenuity.
Application of Antibody Conjugation
Antibody conjugates have been widely used in antigen detection and disease diagnoses, such as proteins identification and cancerous tumors diagnosis, involving chromogenic immunohistochemistry (CIH) and immunofluorescence technologies. Improvements in the methods for antibody conjugate synthesis promote the development of antibody-drug conjugates (ADCs), which sensitively distinguish healthy tissues from diseased tissues for targeting cancer while minimizing healthy tissue exposure. As a new class of biomolecules, antibody-oligonucleotide conjugates (AOCs) have become important biotechnology for imaging, detection, and therapeutics such as targeted siRNA and antisense delivery.
Our Advantages
- Profound knowledge and extensive experience in antibody conjugation
- Comprehensive antibody conjugation service and leading antibody technology
- People and suites that specialize in ADC development, manufacturing and testing
- High levels of antibody recovery so to save your precious reagents
- Full technical support
- Reliable and reproducible result
- Detailed report and data analysis, including results and discussion
Project Workflow
Related Links
PEG conjugated antibodies offer reduced immunogenicity, enhanced solubility, stability and improved bioavailability compared to prototype antibodies while retaining the maximum biological activity.
Biotin-labeled antibodies are endowed with strong affinity for streptavidin and avidin, which can be used in histocytochemistry, immunoassays, and fluorescence-based flow cytometry.
Fluorescence Labeling of Antibody
Fluorophore-labeled antibodies retain antibodies activity and exert additional fluorescent tracer effects. Fluorescent dyes, including FITC, rhodamine, cy3, cy5, etc., can be used to label antibodies.
Antibody labeling antibodies is mainly used for antigen localization analysis. Various reporting enzymes, such as horseradish peroxidase (HRP) and many other enzymes, can bind to antibodies.
Antibody Oligonucleotide Conjugation
Antibody-oligonucleotide conjugates (AOCs) have been widely used in many diagnosis and treatment applications, such as biomarker discovery, clinical diagnosis, and protein-protein interactions.
Antibody-drug conjugates (ADCs) combine the monoclonal antibodies targeting capability and cancer-killing of cytotoxic drugs, can target cancer while minimizing exposure to healthy tissue.
FAQ
1. What is the conjugate of an antibody?
Antibody conjugates are complexes that link antibodies to other molecules (e.g., drugs, polymers, enzymes, etc.) by chemical or biotechnology. This conjugation enhances the targeting of antibodies, allowing them to more precisely identify and attack specific pathological cells or tissues.
2. What are antibody PROTAC conjugates?
Antibody PROTAC conjugates are an emerging form of drug that binds antibodies to PROTACs (protein degradation targeted chimeras) for the targeted degradation of specific proteins. This conjugate has potential applications in the treatment of diseases such as cancer, enhancing efficacy by targeting the removal of disease-causing proteins.
3. What is antibody conjugate structure?
The structure of an antibody conjugate typically consists of an antibody, a linker, and a functional molecule such as a drug, polymer, or other bioactive molecule. Antibodies are responsible for target recognition, linkers regulate the stability and release of conjugates, and functional molecules are directly involved in treatment or diagnosis.