PEG Conjugated Carbohydrate

BOC Sciences aims to provide global clients with PEG carbohydrate conjugation service. As a leading service provider in drug discovery, BOC Sciences is absolutely competent and devoted to providing one-stop PEGylation services.

What is PEGylated Carbohydrate?

PEGylated carbohydrate is the process of chemically coupling a polyethylene glycol (PEG) to a carbohydrate molecule. In this coupling, the carbohydrates can be monosaccharides, oligosaccharides or polysaccharides, etc. PEG has a certain resistance to protein adsorption and recognition by the immune system, which is known as "antigenic camouflage". Coupling PEG with carbohydrates can form a protective shell of PEG in the body, reducing the speed of its recognition and removal, thus prolonging its circulation time in the body and improving the efficacy of the drug. In addition, carbohydrate PEGylation can improve their stability and biocompatibility in vivo, as well as enhance targeting by changing the length of the PEG chain and functionalized modifications for more precise drug delivery and therapeutic effects.

Fig.1 PEGylation of lactose analogs. (Giorgi et al., 2014)

Carbohydrate PEGylation Services

BOC Sciences specializes in PEGylation services for all types of molecules and offers several types of coupling methods.

• Chemical Coupling Methods

Chemical coupling involves creating a covalent linkage between the PEG and the target carbohydrate. Typically, a chemical functional group, such as a carboxylic acid, activated ester, isocyanate, etc., is introduced at one end of the PEG, while the carbohydrate has a corresponding reactive functional group. By means of appropriate reaction conditions, such as an activator or a cross-linking agent, a coupling reaction between the PEG and the carbohydrate.

• Physical Adsorption Methods

This method binds PEG to carbohydrates through physical interactions. In this case, the PEG is usually a linear polymer with a certain length and the carbohydrate surface is hydrophilic. By simple mixing and stirring, the PEG can be adsorbed on the carbohydrate surface.

• Nanoparticle or Carrier Encapsulation Methods

This method encapsulates PEG compounds in nanoparticles or carriers by using them as surfactants or encapsulants. In this process, the PEG compound can interact with the surface of the nanoparticles or carriers to form an encapsulated layer.

Type of PEGylated Carbohydrates

We can offer our customers a wide range of PEGylation of carbohydrates.

• PEGylation of Galactose

PEGylation of galactose is the process of chemically linking a PEG to a galactose molecule. Galactose is a naturally occurring monosaccharide molecule found in lactose that has certain biological activities and specific recognition properties. Conjugation of PEG to galactose can extend their applications in areas such as drug delivery, biosensors and biomaterials.

• PEGylation of Mannose

Mannose is a monosaccharide molecule that occurs naturally in many plants and microorganisms.

• PEGylation of Chitosan

By coupling PEG to chitosan, it is possible to combine the water solubility, stability and bioactivity of PEG with the biocompatibility, drug encapsulation ability and antimicrobial activity of chitosan.

• PEGylation of Fructans

PEGylated fructans can be used to construct biomaterials and tissue engineering scaffolds that are biocompatible and biodegradable.

Our Advantages

• Site-directed PEGylation
• Multiarm PEGylation with more available sites for glycan linking
• Advanced equipment and technique with highly reliable and reproducible result
• Strict monitoring process with HPLC and MS analyses

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