BOC Sciences aims to provide global clients with PEG carbohydrate conjugation service. As a leading service provider in drug discovery, BOC Sciences is absolutely competent and devoted to providing one-stop PEGylation services.
PEGylated carbohydrate is the process of chemically coupling a polyethylene glycol (PEG) to a carbohydrate molecule. In this coupling, the carbohydrates can be monosaccharides, oligosaccharides or polysaccharides, etc. PEG has a certain resistance to protein adsorption and recognition by the immune system, which is known as "antigenic camouflage". Coupling PEG with carbohydrates can form a protective shell of PEG in the body, reducing the speed of its recognition and removal, thus prolonging its circulation time in the body and improving the efficacy of the drug. In addition, carbohydrate PEGylation can improve their stability and biocompatibility in vivo, as well as enhance targeting by changing the length of the PEG chain and functionalized modifications for more precise drug delivery and therapeutic effects.
Fig.1 PEGylation of lactose analogs. (Giorgi et al., 2014)
BOC Sciences specializes in PEGylation services for all types of molecules and offers several types of coupling methods.
Chemical coupling involves creating a covalent linkage between the PEG and the target carbohydrate. Typically, a chemical functional group, such as a carboxylic acid, activated ester, isocyanate, etc., is introduced at one end of the PEG, while the carbohydrate has a corresponding reactive functional group. By means of appropriate reaction conditions, such as an activator or a cross-linking agent, a coupling reaction between the PEG and the carbohydrate.
This method binds PEG to carbohydrates through physical interactions. In this case, the PEG is usually a linear polymer with a certain length and the carbohydrate surface is hydrophilic. By simple mixing and stirring, the PEG can be adsorbed on the carbohydrate surface.
This method encapsulates PEG compounds in nanoparticles or carriers by using them as surfactants or encapsulants. In this process, the PEG compound can interact with the surface of the nanoparticles or carriers to form an encapsulated layer.
We can offer our customers a wide range of PEGylation of carbohydrates.
PEGylation of galactose is the process of chemically linking a PEG to a galactose molecule. Galactose is a naturally occurring monosaccharide molecule found in lactose that has certain biological activities and specific recognition properties. Conjugation of PEG to galactose can extend their applications in areas such as drug delivery, biosensors and biomaterials.
Mannose is a monosaccharide molecule that occurs naturally in many plants and microorganisms.
By coupling PEG to chitosan, it is possible to combine the water solubility, stability and bioactivity of PEG with the biocompatibility, drug encapsulation ability and antimicrobial activity of chitosan.
PEGylated fructans can be used to construct biomaterials and tissue engineering scaffolds that are biocompatible and biodegradable.
Our Advantages
Project Workflow
Yes, PEGylation can be applied to natural polysaccharides to enhance their solubility, stability, and biocompatibility. By modifying the polysaccharide with PEG, it becomes more resistant to enzymatic degradation, making it more durable and functional for applications in biotechnology, food science, and materials development.
PEGylation of carbohydrates improves their performance in sensor technology by increasing their stability and resistance to environmental factors. The PEG modification also reduces non-specific binding, enhancing the specificity of carbohydrate-based sensors and ensuring more accurate and reliable readings in various detection applications.
PEG conjugation alters the carbohydrate's molecular interactions by preventing aggregation and enhancing its solubility in aqueous environments. The PEG layer can shield the carbohydrate's reactive sites, reducing unwanted interactions with other molecules and improving the precision of its performance in various biochemical applications.
Reference
