Gold Nanoparticles labeled RNA

As a specialized provider of biochemical services, BOC Sciences has a comprehensive range of state-of-the-art platforms. We can provide you with comprehensive solutions for gold nanoparticle labeled RNA for customers worldwide, meeting specific needs to advance your research.

RNA Functionalized Gold Nanoparticles

Gold nanoparticle labeled RNA is a method of combining gold nanoparticles with RNA molecules for the detection and imaging of RNA molecules. This technique takes advantage of the unique optical properties of gold nanoparticles and the specific recognition of RNA to enable visualization and quantitative analysis of RNA molecules. The advantages of gold nanoparticle labeled RNA include the following.

Stability - Gold nanoparticles have good stability and can maintain their structure and properties under different conditions. This stability allows gold nanoparticle-labeled RNA to maintain its reliability and consistency during sample processing and analysis.

Versatility - By introducing different functional molecules, such as antibodies, drugs, polymers, etc., on the surface of gold nanoparticles, gold nanoparticle-labeled RNA can be made to have additional functions, such as targeted delivery, drug release, and therapy.

Easy to synthesize and manipulate - Gold nanoparticle labeled RNA is relatively easy to obtain and its preparation method is simple.

Fig.1 Examples of RNA-gold nanoparticle. (Graczyk et al., 2020)

RNA Gold Nanoparticle Services

BOC Sciences has extensive experience in labeling nanoparticles and can facilitate the development of labeling projects for our customers in biomedical, nanotechnology, and other fields. Currently, our services include customization, modification, precision regulation, and characterization of gold nanoparticle-labeled RNA.

We will clarify your needs and product applications to develop a unique protocol for gold nanoparticle-labeled RNA. We are capable of customizing different types of gold nanoparticles for RNA labeling. Meanwhile, we can also provide the a variety of RNA labeling services, including:

• Gold nanoparticles labeling of mRNA
• Gold nanoparticles labeling of tRNA
• Gold nanoparticles labeling of rRNA
• Gold nanoparticles labeling of siRNA

Gold nanoparticles are modified with specific amounts and orientations of RNA to facilitate nanoparticle assembly. At BOC Sciences, precise regulation of the amount of RNA modified on gold nanoparticles can be achieved through optimization of reaction conditions, kinetic control, modifier concentration control, gold nanoparticle surface modification, and reaction monitoring.

Gold Nanoparticles for Labeling RNA

Gold nanoparticles can obtain high stability, biocompatibility, targeting, and other properties after modification, which can optimize the effect of gold nanoparticles labeling RNA. BOC Sciences provides the following modification services according to the properties of gold nanoparticles and RNA itself.

• Functional cluster-modified gold nanoparticles for labeling RNA
  The surface of gold nanoparticles can be modified to introduce functional groups to bind to RNA. Modifications include amination modification, thiolation, and phosphorylation. These functionalized gold nanoparticles can achieve selective binding and labeling of RNA by interacting with specific functional groups in the RNA molecule.

• Nuclease-protected gold nanoparticles
  Nuclease-modified gold nanoparticles form a protective layer that prevents the degradation of RNA molecules and can simultaneously bind to RNA molecules.

Detection of RNA Gold Nanoparticles

• Ultraviolet-Visible Absorption Spectroscopy (UV-Vis)
• Fluorescence Detection
• Surface Enhanced Raman Scattering (SERS)
• Electrochemical Detection