The gold nanoparticles provided by BOC Sciences have high efficiency and sensitivity in applications in the fields of chemistry, biological analysis, biomedicine, optics and nanotechnology. With a comprehensive advanced platform, BOC Sciences provides gold nanoparticles labeled RNA services to customers worldwide to promote your research.
In recent years, the use of functionalized gold nanoparticles has enabled sensitive detection of nucleic acids, small molecules, and cells. These tests are based on the “cross-linking aggregation” method, which uses the interaction between the modified ligand (RNA or DNA) on the surface of the functionalized gold nanoparticles and the target analyte to overcome the repulsive force between the particles to aggregate. Because the color of gold nanoparticles is more sensitive to aggregation, the target analyte can be detected by observing the color change.
Messenger RNA (mRNA) is closely related to many human genetic diseases, and abnormal expression of mRNA can often be observed in the early stages of cancer. Therefore, sensitive detection of specific mRNAs is of great significance for the early clinical diagnosis of hereditary diseases (tumor etc.). Gold nanoparticles are bound to mRNAs, and the number of mRNAs in cells or in vivo can be determined by detecting special signals generated when light interacts with gold nanoparticles. In addition, micro RNA (miRNA) is closely related to human diseases, but it is difficult to detect because it contains fewer bases. Gold nanoparticles labeled miRNA enables highly sensitive visual detection of miRNA.
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