Relying on years of experience, BOC Sciences can provide gold nanoparticles in various sizes for labeling peptides. We guarantee that each customized project is strictly monitored according to the quality control standards.
Gold nanoparticle-labeled peptides are produced by combining gold nanoparticles with specific peptide sequences and are used for visualization, detection or localization of cells, tissues or biomolecules. Gold nanoparticle-labeled peptides have unique optical and electronic properties, and their assembly can be triggered by changes in the local environment. An increasing number of studies are applying these properties to biomedical applications, such as the detection of metal ions, enzymes and antibodies.
Fig.1 Gold nanoparticles are stabilized by a peptide amphiphile. (Egorova et al., 2020)
BOC Sciences offers customized services for labeling peptides with gold nanoparticles, including ultra-small gold particles, and our researchers will select the optimal labeling strategy
| Labeling Services | Specification |
| Gold Nanoparticle Labeled Signal Peptides | Signal peptides affect cellular function and behavior by binding to specific receptors on the cell surface and triggering a series of signal transduction pathways. BOC Sciences offers solutions for visualizing and detecting signal peptides by combining gold nanoparticles with signal peptides. |
| Gold Nanoparticle Labeled Neuropeptides | Neuropeptides are short peptides that play a role in regulating and transmitting information in the nervous system. Neuropeptides bind to the modified gold nanoparticles through covalent or non-covalent bonds, and are stably attached to the surface of gold nanoparticles. |
| Gold Nanoparticle Labeled Antimicrobial Peptide | BOC Sciences designs gold nanoparticle labeling experiments based on the antimicrobial peptides supplied by our clients. Our technicians will then use advanced technology to combine the gold nanoparticles with the antimicrobial peptide, and measure the performance of the product after completion to ensure that it is as effective as the customer requires. |
| Gold Nanoparticle Labeled Cell-penetrating Peptide | Cell-penetrating peptides (CPPs) are a class of short peptides that are able to cross cell membranes or tissue barriers. depending on the needs of the customer, BOC Sciences can modify gold nanoparticles so that they can bind better to cell-penetrating peptides. Subsequently, we provide cell penetration assays to evaluate the localization and effect of the gold nanoparticle-labeled cell-penetrating peptide within the cell. |
Characterization of gold nanoparticle-labeled peptides can be performed using ultraviolet-visible (UV-Vis) absorption spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), and electrochemical measurements.
Yes, our gold nanoparticle-labeled peptides are designed for both in vitro and in vivo applications. We offer customized solutions to optimize labeling for specific environments, including cellular assays and animal models.
We use rigorous quality control procedures, including size and morphology analysis through TEM and UV-Vis spectroscopy, to ensure that our gold nanoparticles meet your specifications before labeling.
Covalent binding forms a stable chemical bond between the peptide and nanoparticle, non-covalent binding relies on weaker interactions like electrostatic forces, and affinity binding utilizes specific interactions, such as biotin-streptavidin, to achieve high selectivity.
Yes, we offer surface modifications to improve peptide binding, such as introducing functional groups to the gold nanoparticle surface for stronger covalent or non-covalent interactions with peptides.
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