Enzymatic Crosslinking Services

* Please kindly note that our services can only be used to support research purposes (Not for clinical use).

The ability of enzymes to promote the formation of covalent cross-linking between protein amino acid residues provides a variety of possibilities for protein modification, which complements the limitations of chemical cross-linking methodology. As a leading service provider in the field of drug discovery and research, we provide a majority of enzymatic crosslinking services.


Despite the wide commercial availability, reaction efficiency and versatility of chemical cross-linking agents, their applications in food processing and tissue engineering are particularly disadvantageous because many of these compounds are rated as toxic or may form harmful by-products leached from the cross-linked protein matrix. In order to overcome these limitations, much attention has been paid to the study of enzymes that catalyze the formation of protein cross-links in vitro. This allows site-directed coupling of proteins with different properties and ab initio assembly of polymerized protein networks. Transferase, hydrolase and redox enzyme can be used as catalysts for the synthesis of cross-linked proteins, thus complementing the chemical cross-linking strategy.


In various application fields that require biological protein matrix with similar structural and mechanical properties, the method of covalent assembly of proteins into macromolecular networks by enzyme catalysis has been widely studied. For example, the ability of enzymes to form cross-linked protein networks has been used to change the texture and appearance of foods, to develop new biomimetic tissue scaffolds or to enhance protein-based fibers for textile manufacturing.

Our Advantages

  • Provide a variety of possibilities for protein modification
  • Extensive Enzymatic Crosslinking Strategy
  • High specificity and minimal side effects.
  • Cross-linking at a specific location
  • Well-trained biological and organic chemists
  • Guaranteed Quality
  • Data analysis & report delivery
  • 24h-available customer service

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