Antibody Oligonucleotide Conjugation

* Please kindly note that our services can only be used to support research purposes (Not for clinical use).

BOC Sciences is a recognized leader in providing high quality antigen and antibody coupling services. With a wealth of experience and advanced technology, we can now provide you with the specific antibody-oligonucleotide conjugation.


Conjugation is a process in which two molecules/polymers or biomolecules/biopolymers are covalently linked together. Studies have shown that antibody molecules have many functional groups suitable for modification or conjugation purposes. Antibody-oligonucleotide conjugates or AOC belong to a class of chimeric molecules that bind to two important families of biomolecules: monoclonal antibodies and oligonucleotides. Cross-linked oligonucleotides-antibodies can be achieved by lysine and N-terminal groups. The combination of the excellent targeting ability of monoclonal antibodies and many functional forms of oligonucleotides has achieved fruitful results in various applications of AOC, including imaging, detection and targeted therapy.


In the past few years, the emergence of oligonucleotide antibodies provides an effective and accurate method for the detection of low abundance proteins. In addition, oligonucleotide antibodies have been widely used in many applications from diagnosis to treatment, such as biomarker discovery, clinical diagnosis and protein-protein interactions. In addition to conjugating with antibodies, oligonucleotide-semi-antibody conjugation has also been developed for therapeutic and diagnostic applications.

Our Advantages

  • Performed by trained professionals
  • Evidence of successful conjugation provided
  • Conjugate at required antibody–oligo ratio and scale
  • Fast turnaround time
  • Full technical support
  • High levels of antibody and oligo recovery so you save precious reagents.

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Antibody Oligonucleotide Conjugation

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